[發明專利]輻射發射肽核酸綴合物及其用于疾病、狀況和紊亂的診斷、成像和治療的用途

在審

• 申請號: 201680057550.4
• 申請日: 2016-08-11
• 公開（公告）號: CN108348622A
• 公開（公告）日: 2018-07-31
• 發明（設計）人: 艾倫·雅文;亞伯拉罕·魯賓斯坦;內塔內爾·科萊夫松
• 申請（專利權）人: 耶路撒冷希伯來大學伊森姆研究發展有限公司
• 主分類號: A61K49/00
• 分類號: A61K49/00
• 代理公司: 北京安信方達知識產權代理有限公司 11262
• 代理人: 高瑜;鄭霞

本發明提供一種包含至少一種輻射發射探針和至少一種基因互補組分的綴合物、含有所述綴合物的組合物和其試劑盒，所述綴合物用于在對狀況、疾病和紊亂的高靈敏度診斷、成像和治療中使用。

技術領域

本發明提供一種用于狀況、疾病和紊亂的高靈敏度診斷、成像和治療的輻射發射(紅光到近紅外光)PNA綴合物。

背景技術

[1]Maebert,K.,Cojoc,M.,Peitzsch,C.,Kurth,I.,Souchelnytskyi,S.,andDubrovska,A.(2014)Cancer biomarker discovery:Current status and futureperspectives,Int.J.Radiation Biol.90,659-677.

[2]Brink,M.,De Goeij,A.F.P.M.,Weijenberg,M.P.,Roemen,G.M.J.M.,Lentjes,M.H.F.M.,Pachen,M.M.M.,Smits,K.M.,De Bruine,A.P.,Goldbohm,R.A.,andVan Den Brandt,P.A.(2003)K-ras oncogene mutations in sporadic colorectalcancer in The Netherlands Cohort Study,Carcinogenesis 24,703-710.

[3]Heinzerling,L.,Baiter,M.,Kuehnapfel,S.,Schuler,G.,Keikavoussi,P.,Agaimy,A.,Kiesewetter,F.,Hartmann,A.,and Schneider-Stock,R.(2013)Mutationlandscape in melanoma patients clinical implications of heterogeneity of BRAFmutations,British Journal of Cancer 109,2833-2841.

[4]Martinez-Garza,S.G.,Nunez-Salazar,A.,Calderon-Garciduenas,A.L.,Bosques-Padilla,F.J.,Niderhauser-Garcia,A.,and Barrera-Saldana,H.A.(1999)Frequency and clinicopathology associations of K-ras mutations in colorectalcancer in a northeast Mexican population,Digestive Diseases 17,225-229.

[5]Rasuck,C.G.,Leite,S.M.O.,Komatsuzaki,F.,Ferreira,A.C.S.,Oliveira,V.C.,and Gomes,K.B.(2012)Association between methylation in mismatch repairgenes,V600E BRAF mutation and microsatellite instability in colorectal cancerpatients,Mol.Biol.Reports 39,2553-2560.

[6]Dahan,L.,Huang,L.,Kedmi,R.,Behlke,M.A.,and Peer,D.(2013)SNPdetection in mRNA in living cells using allele specific FRET probes,PloS one8,e72389.

[7]Bos,J.L.(1989)Ras oncogenesis in human cancer-a review CancerRes.49,4682-4689.